BioMediTech Research Groups

Micro- and Nanosystems Research Group

Group Leader: Professor Pasi Kallio

pasi.kallio(at)tut.fi

About Us

The mission of Micro- and Nanosystems Research Group is to develop automatic and autonomous systems for handling, processing, stimulating and characterizing micro- and nanoscale samples and objects. We combine knowledge of automation and control engineering with microsystems and nanotechnology and develop novel functional systems in selected application areas.

For more information please visit: Micro- and Nanosystems Research Group page at TUT website

Research interests and expertise

Our main expertise areas include microfluidics, micromechatronics and microrobotics. We focus our research on microfluidic organ-on-chip systems and microrobotic characterization of microscopic fiber materials. In organ-on-chip systems, our interests are in microfluidic perfusion and gas supply and mechanical stimulation concepts. We have developed solutions for miniaturized hypoxia chambers, molecule permeation studies and equiaxial and uniaxial cell stretching. In microrobotic fiber characterization, we have developed solutions to characterize tensile and bending properties, fiber-fiber bonding strength and fiber-matrix interfacial strength for pulp, glass and carbon fibers.

Achievements

  • Development of modular stem cell culture environment
  • Development of portable hypoxia concept (patent pending)
  • Development of microrobotic fiber testing concepts (patents pending)
  • Finnish Automation Society Award

Infrastructure

  • Microrobotic testing systems for fiber and soft material studies
  • Clean room facilities for fabrication of microscale devices and components
  • Fabrication and testing facilities for microfluidic systems

Collaboration offer and requests

We offer system design and fabrication expertise in microfluidics and microrobotics. We offer also pilot systems for hypoxia and drug permeation studies and service for various single fiber tests and experiments.

Major Publications

  1. Kreutzer J, Ylä-Outinen L, Mäki A-J, Ristola M, Narkilahti S, Kallio P. Cell Culture Chamber with Gas Supply for Prolonged Recording of Human Neuronal Cells on Microelectrode Array. Journal of Neuroscience Methods. Volume 280, 15 March 2017, pp. 27-35.
  2. Mäki A-J, Peltokangas M, Kreutzer J, Auvinen S, Kallio P. Modeling Carbon Dioxide Transport in PDMS-based Microfluidic Cell Culture Devices. Chemical Engineering Science, Volume 137, 1 December 2015, Pages 515–524.
  3. Saketi P, Latifi SK, Hirvonen H, Rajala S, Vehkaoja A, Salpavaara T, Lekkala J, Kallio P. PVDF Microforce Sensor for the Measurement of Z-directional Strength in Paper Fiber Bonds. Sensors & Actuators: Physical. Volume 222, Issue 1, February 2015, pp 194–203.
  4. Kreutzer J, Ikonen L, Hirvonen J, Pekkanen-Mattila M, Aalto-Setälä K and Kallio P. Pneumatic Cell Stretching System for Cardiac Differentiation and Culture. Medical Engineering & Physics, Volume 36, No 4, April 2014, pp. 496-501. DOI: 10.1016/j.medengphy.2013.09.008
  5. Hemmilä S, Cauich-Rodríguez JV, Kreutzer J, Kallio P. Rapid, simple, and cost-effective treatments to achieve long-term hydrophilic PDMS surfaces. Applied Surface Science. Volume 258, Issue 24, October 2012, pp. 9864–9875.
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