BioMediTech Research Groups

Biophysics of the Eye

Group Leader: Academy Research Fellow Soile Nymark

soile.nymark(at)tut.fi

About Us

Biophysics of the Eye research group focuses on the visual system and its functioning in health and disease. The group uses electrophysiological, imaging and cell biological approaches to investigate the retina and retinal pigment epithelium (RPE) in the eye. The overarching goal of the group is to increase the understanding of the visual system overall as well as to advance the development of novel ocular therapies. The group works in close collaboration with the research group of Professor Jari Hyttinen.

For more information, please visit the Nymark lab webpage.

Research interests and expertise

Our primary research interests are the following:

  • Retina – RPE interaction
  • Ion channel functionality of native and stem cell derived RPE
  • Disease mechanisms of retinal degenerative diseases

Our expertise is focused around electrophysiology (patch clamp technique, microelectrode array (MEA), electroretinogram), imaging methods (calcium imaging, confocal microscopy, super resolution microscopy (SIM)) as well as cell and molecular biological methods.

Infrastructure

In our research, we utilize BioMediTech’s Research Infrastructure.

Major Publications

  1. Berry J, Frederiksen R, Nymark S, Yao Y, Chen J, Cornwall MC. (2016) Effect of Rhodopsin Phosphorylation on Dark-Adaptation in Mouse Rods. Journal of Neuroscience. 36(26):6973-6987.
  2. Frederiksen R*, Nymark S*, Kolesnikov A, Berry J, Adler IV L, Koutalos Y, Kefalov V, Cornwall MC. (2016) Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods. Journal of General Physiology. 148(1):1-11. *Equal contributions
  3. Vainio I, Abu Khamidakh A, Paci M, Skottman H, Juuti-Uusitalo K, Hyttinen J, Nymark S. (2015) Computational Model of Ca2+ Wave Propagation in Human Retinal Pigment Epithelial ARPE-19 Cells. PLoS ONE. DOI: 10.1371/journal.pone.0128434.
  4. Wang J-S, Nymark S, Estevez M.E, Frederiksen R, Shen S, Razafsky D, Hodzic D, Corbo J.C, Cornwall M.C, Kefalov V.J. (2014) Chromophore supply rate-limits mammalian photoreceptor dark adaptation. Journal of Neuroscience. 34:11212-21.
  5. Tervonen A, Vainio I, Nymark S, Hyttinen J. (2014) Prediction of Passive Drug Permeability Across the Blood-Retinal Barrier. Pharmaceutical Research. 31(9):2297-2311.
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