BioMediTech Research Groups

Biomaterials and Tissue Engineering Group

Group Leader: Professor Minna Kellomäki

minna.kellomaki(at)tut.fi

About Us

Our research has a long history in the field of biomedical engineering related to the implants and biomaterials, specialized in biodegradable, medical polymers and composites. The work at TUT started in 1970’s by now retired professor Pertti Törmälä. We have always worked in close collaboration with clinicians and biologists interested in solving biomedical problems, and we continue to follow this practice.

We study mainly bioabsorbable polymers, hydrogels, bioactive glasses and composites of them. We have expertise in both synthetic and biologically modified materials. Currently we have research starting from synthesis, going through the characterization, functionalization and processing to the end-products. Our aim is to develop functionalized devices and scaffolds to the biological and clinical applications.

We are working in close collaboration with the research groups of Associate Professor Jonathan Massera and Assistant Professor Oommen P. Oommen.

Research interests and expertise

Research interests:

  • Tissue Engineering
  • Novel hydrogel synthesis
  • Functionalization of polymers
  • Influence of topology to the cell attachment, proliferation and differentiation
  • Biologically functional composites
  • Biodegradable sensors

Expertise:

  • Synthesis and functionalization of polymers and hydrogels for medical applications
  • Biomaterial characterization techniques (thermal, chemical and mechanical characterization, Atomic Force Microscopy (AFM))
  • Processing of bioabsorbable polymers and composites
  • Two photon polymerisation (2PP)

Infrastructure

  • Clean room for biomaterial production
  • Dark room for light sensitive reactions etc.
  • Glove box (N2) for air and/or moisture sensitive reagents etc.
  • Single- and twin-screw extruders
  • Pilot-scale textile machines to produce implantable scaffolds and devices
  • Freeze-dryer
  • Super critical CO2 –reactor for scaffold production
  • Direct laser writing by two-photon polymerization
  • Analysis and characterization of polymers (e.g. GPC, DSC, TG, UV-Vis, GC, mechanical testing, AFM)

Major Publications

  1. Calejo MT, Ilmarinen T, Jongprasitkul H, Skottman H, Kellomäki M. (2016). Honeycomb porous films as permeable scaffold materials for human embryonic stem cell‐derived retinal pigment epithelium. Journal of Biomedical Materials Research Part A, 104(7), 1646-1656.
  2. Karvinen J, Koivisto JT, Jönkkäri I, Kellomäki M. (2017). The production of injectable hydrazone crosslinked gellan gum-hyaluronan-hydrogels with tunable mechanical and physical properties. Journal of the Mechanical Behavior of Biomedical Materials, 71, 383-391.
  3. Koivisto J, Joki T, Parraga J, Pääkkönen R, Ylä-Outinen L, Salonen L, Jonkkari I, Peltola M, Ihalainen TO, Narkilahti S, Kellomäki M. (2017). Bioamine-crosslinked gellan gum hydrogel for neural tissue engineering. Biomedical Materials, 12(2), 025014.
  4. Salpavaara T, Hänninen A, Antniemi A, Lekkala J, Kellomäki M. (2017). Non-destructive and wireless monitoring of biodegradable polymers. Sensors and Actuators B: Chemical, 251, 1018-1025.
  5. Turunen S, Joki T, Hiltunen ML, Ihalainen TO, Narkilahti S, Kellomaki M. (2017). Direct Laser Writing of Tubular Microtowers for 3D Culture of Human Pluripotent Stem Cell-Derived Neuronal Cells. ACS Applied Materials & Interfaces, 9(31), 25717-25730.
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