BioMediTech Research Groups

Bioengineering and Nanomedicine Group

Group Leader: Assistant Professor Oommen P. Oommen

oommen.oommen(at)tut.fi

About Us

The Bioengineering and Nanomedicine group is founded upon cutting-edge multi-disciplinary research in the areas of biomaterials, tissue engineering, drug delivery, nanomedicine, cell-based therapy and immunotherapy. We are a part of the Biomaterials and Tissue Engineering group at BioMediTech-Tampere University of Technology at the Faculty of Biomaterial Sciences and Engineering. The main goal of our research is to use natural polymers present in our extracellular matrix (ECM) to design materials and drug delivery systems for immunomodulation and biomedical applications. To know more about our research please visit http://www.tut.fi/oommen-lab/.

Research interests and expertise

Research interests:

  • Engineering Nanocarriers: We design nanocarriers using biomaterials for drug and gene delivery applications. Biopolymers such as hyaluronic acid (HA) and chondroitin sulfate (CS) target cell surface CD44 receptors overexpressed in several solid tumors. We have shown that CS derived gold nanoparticles and nanoplexes significantly enhance the drug delivery and gene delivery efficiency and suppress side-effects.
  • Regenerative Medicine: Hydrogels derived from ECM polymers provide ideal cellular niche for culturing stem cells and other cell lines. The 3D scaffold designed from these polymers mimics tissue environment and can be potentially used for drug screening and for tissue engineering applications.
  • Immunoisolation of cells for transplantation: One of our primary goal of our research is to develop single cell coating strategy to improve the in vivo survival and therapeutic outcome of clinically relevant cells such as mesenchymal stem cells and islet cells. We use the ECM derived polymers to achieve this objective using layer-by-layer assembly or by chemical conjugation technique.
  • Immunomodulation of drugs and material surfaces: The adverse side effects of chemotherapeutic drugs and implantable materials are due to the activation of immune system. We aim to mitigate the interaction of materials and drugs with blood components by developing antifouling surfaces and encapsulation of toxic drugs in different nanoformulations.
  • Novel bioconjugation strategies: Being trained in organic chemistry, we always look for new endeavors to develop novel chemistries that could be performed under aqueous conditions in presence of cells.

Expertise: Organic chemistry, polymer chemistry, nanoformulation, 3D scaffold design, cell culture, immunotherapy, tissue engineering

Major Publications

  1. Gurav D, Varghese OP, Hamad OA, Nilsson B, Hilborn J, Oommen OP. Chondroitin Sulfate Coated Gold Nanoparticles: A New Strategy to Resolve Multidrug Resistance and Thromboinflammation. Chem Commun 2016, 52, 966-969 (Link)
  2. Oommen OP, Duehrkop C, Nilsson B, Hilborn J, Varghese OP. Multifunctional Hyaluronic Acid and Chondroitin Sulfate Nanoparticles: Impact of Glycosaminoglycan Presentation on Receptor Mediated Cellular Uptake and Immune Activation. ACS Applied Materials and Interface, 2016, 8, 20614–20624 (Link)
  3. Tengdelius M, Gurav D, Konradsson P, Påhlsson P, Griffith M, Oommen OP. Synthesis and Anticancer Properties of Fucoidan-Mimetic Glycopolymer Coated Gold Nanoparticles. Chem Commun 2015, 51, 8532-8535 (Link)
  4. Yan H, Oommen OP, Yu D, Hilborn J, Qian H, Varghese OP. Chondroitin Sulfate-Coated DNA-Nanoplexes Enhance Transfection Efficiency by Controlling Plasmid Release from Endosomes: A New Insight into Modulating Nonviral Gene Transfection. Adv. Funct. Mater., 2015, 25, 3907–3915. (Link)
  5. Oommen OP, Wang S, Kisiel M, Sloff M, Hilborn J, Varghese OP. Smart design of stable extracellular matrix mimetic hydrogel: synthesis, characterization, in vitro and in vivo evaluation for tissue engineering. Adv. Funct. Mater., 2013, 23, 1273–1280. (Link)
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